Effect of Physical Activity on Metabolic Syndrome in Pregnancy & Fetal Outcome
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Central adiposity
研究概览
简要总结
The purpose of this study is to examine the effect of exercise during pregnancy upon maternal metabolism, including weight gain, fat distribution, and levels of glucose and cholesterol. We will also conduct a pilot study to examine the feasibility of studying the health of infants born to women in this study.
详细描述
Obesity and overweight have become important public health problems in the United States, and measures are urgently needed to address these issues. For many women, pregnancy is a time of excessive weight gain and decreases in physical fitness, both of which may be followed by postpartum weight retention. Women who develop hypertension or diabetes mellitus during pregnancy are at higher risk for development of these disorders in the future. Because of the implications of pregnancy-related weight gain and the metabolic changes during pregnancy for future maternal health, interventions to maintain or improve fitness during pregnancy may have important downstream health effects. In addition, maternal metabolic parameters and the intra-uterine environment have important implications for neonatal outcomes and subsequent child health. This study will provide data about the effects of an intervention to increase vigorous physical activity during pregnancy on short-term maternal and fetal outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women 18-45 years old receiving prenatal care at MAMC
排除标准
- •Women do not have a gallbladder
- •Who do not speak English
- •Are over 14 weeks pregnant at study entry
- •Do not plan to deliver at MAMC
- •Have medical contraindications
- •Unwilling to participate in exercise intervention program
- •Are under 18 years of age
- •Currently engaged in a regular vigorous exercise program
结局指标
主要结局
Central adiposity
时间窗: 6-8 weeks postpartum
次要结局
- neonatal adiposity(birth)
- Leptin levels(during pregnancy and postpartum)
- glucose(during pregnancy and postpartum)
- insulin(during pregnancy and postpartum)
- fetal adiposity(35-36 weeks gestation)
- cholesterol(during pregnancy and postpartum)
