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临床试验/NCT00647595
NCT00647595已完成3 期

Effect of Physical Activity on Metabolic Syndrome in Pregnancy & Fetal Outcome

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2007年10月最近更新:
适应症

试验速览

阶段
3 期
状态
已完成
入组人数
100
试验地点
2
主要终点
Central adiposity

研究概览

简要总结

The purpose of this study is to examine the effect of exercise during pregnancy upon maternal metabolism, including weight gain, fat distribution, and levels of glucose and cholesterol. We will also conduct a pilot study to examine the feasibility of studying the health of infants born to women in this study.

详细描述

Obesity and overweight have become important public health problems in the United States, and measures are urgently needed to address these issues. For many women, pregnancy is a time of excessive weight gain and decreases in physical fitness, both of which may be followed by postpartum weight retention. Women who develop hypertension or diabetes mellitus during pregnancy are at higher risk for development of these disorders in the future. Because of the implications of pregnancy-related weight gain and the metabolic changes during pregnancy for future maternal health, interventions to maintain or improve fitness during pregnancy may have important downstream health effects. In addition, maternal metabolic parameters and the intra-uterine environment have important implications for neonatal outcomes and subsequent child health. This study will provide data about the effects of an intervention to increase vigorous physical activity during pregnancy on short-term maternal and fetal outcomes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Single (Investigator)

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • Pregnant women 18-45 years old receiving prenatal care at MAMC

排除标准

  • Women do not have a gallbladder
  • Who do not speak English
  • Are over 14 weeks pregnant at study entry
  • Do not plan to deliver at MAMC
  • Have medical contraindications
  • Unwilling to participate in exercise intervention program
  • Are under 18 years of age
  • Currently engaged in a regular vigorous exercise program

结局指标

主要结局

Central adiposity

时间窗: 6-8 weeks postpartum

次要结局

  • neonatal adiposity(birth)
  • Leptin levels(during pregnancy and postpartum)
  • glucose(during pregnancy and postpartum)
  • insulin(during pregnancy and postpartum)
  • fetal adiposity(35-36 weeks gestation)
  • cholesterol(during pregnancy and postpartum)

研究者

研究点 (2)

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