Optimization of Intestinal Preparation in Older Patients
- Conditions
- ColonoscopyOlder Adults
- Interventions
- Procedure: single administration of low dose polyethylene glycol
- Registration Number
- NCT05397158
- Lead Sponsor
- Beijing Tongren Hospital
- Brief Summary
Older adults are susceptible to intestinal tumors. Colonoscopy can screen colorectal cancer, adenoma and other diseases. There is a large demand for colonoscopy in the older adults, and the risk during peri-colonoscopy period is high. According to the common intestinal preparation methods and the characteristics of the older adults, the investigators propose a modified method, that is single administration of low dose polyethylene glycol (PEG). Specifically, take 30ml lactulose in the morning 1 day before the examination, and eat without residue in lunch and dinner, Take 2L PEG in the morning of the examination day and fast at breakfast and lunch of the day. Taking 4L PEG in 2 days as the control group. The fasting and diarrhea period is shorter in the modified group than that in the control group, and the dose of PEG is less. Lactulose, a laxative, is taken one day before the examination, and the intestinal preparation time is longer than that of single administration. The situation of comfort, sleep and fecal incontinence during the intestinal preparation of the two groups will be compared. The results of electrolyte, blood glucose and B-type brain natriuretic peptide between the two groups will be also compared. The effect of intestinal preparation will be evaluated by the standardization of Boston intestinal preparation scale, and endoscopist blind method will be used in colonoscopy.
- Detailed Description
The participants in control group take 2L PEG the day before the examination, fast at dinner (participants without diabetes) and eat without residue (participants with diabetes). Participants take 2L PEG again in the morning of the examination day, and fasted at breakfast and lunch of the day.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 312
- Age≥ 50y
- Colonoscopy is planned
- Willing to participate
- Age<50y
- Unwilling to participate
- Missing data
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description control group single administration of low dose polyethylene glycol The patients in control group take 2L PEG the day before the examination, fast at dinner (patients without diabetes) and eat without residue (patients with diabetes). Patients take 2L PEG again in the morning of the examination day, and fasted at breakfast and lunch of the day. Single administration of low dose polyethylene glycol group single administration of low dose polyethylene glycol The patients take 30ml lactulose in the morning 1 day before the examination, and eat without residue in lunch and dinner; Take 2L PEG in the morning of the examination day and fast at breakfast and lunch of the day.
- Primary Outcome Measures
Name Time Method Intestinal preparation Cleanliness assessment Up to 1 hour The effect of intestinal preparation will be evaluated by Boston Intestinal Preparation Scale.The minimum score is 0，and the maximum score is 9. Higher scores mean a better outcome. Endoscopist blind method will be used.
- Secondary Outcome Measures
Name Time Method The situation of fecal incontinence during the intestinal preparation One day Fecal incontinence questionnaire. Does the patient have fecal incontinence and the number of fecal incontinence.
Blood potassium level before and after intestinal preparation Up to 1 week Blood potassium in mmol/L.
Blood glucose level before and after intestinal preparation Up to 1 week Blood glucose in mmol/L.
B-type brain natriuretic peptide (BNP) level before and after intestinal preparation Up to 1 week BNP in pg/ml.
The situation of comfort during the intestinal preparation Two days Comfort situation questionnaire. The score of comfort questionnaire is 1 to 10, 1 represents extremely uncomfortable and 10 represents very comfortable.
Blood sodium level before and after intestinal preparation Up to 1 week Blood sodium in mmol/L.
The situation of sleep during the intestinal preparation One day Sleep situation questionnaire. The length of sleep in hour, the number of awakening, the number of urination and defecation.
Trial Locations
- Locations (1)
Beijing Tongren Hospital
🇨🇳Beijing, Beijing, China