Effects of Two Different Doses of Phenylephrine co Administration on Oxytocin- Induced Hemodynamic Effects
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- Number of Hypotensive episodes
研究概览
简要总结
Cesarean section is one of the commonly performed surgical procedures in the world. Once baby is delivered during the surgical procedure anesthesiologist administer Oxytocin drug through IV cannula which helps the Uterus to contract so that excessive blood loss doesnt occur. But this is associated with fall in blood pressure frequently requiring administration of medications to treat low blood pressure. The most frequently used drug is phenylephrine which can administered along with oxytocin to prevent fall in blood pressure. This study will compare to different doses of Phenylephrine to prevent fall in blood pressure.
详细描述
Cesarean section is one of the most commonly performed surgical procedures worldwide. Following delivery of the neonate, oxytocin is routinely administered intravenously to promote uterine contraction and thereby reduce the risk of postpartum hemorrhage. However, oxytocin administration is frequently associated with maternal hypotension, which may necessitate pharmacological intervention. Phenylephrine, a selective α-adrenergic agonist, is commonly used to prevent or treat oxytocin-induced hypotension due to its vasoconstrictive properties. The optimal prophylactic dose of phenylephrine administered concurrently with oxytocin remains uncertain. This study aims to compare two different doses of phenylephrine for the prevention of hypotension following oxytocin administration during cesarean section.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •- Females having a singleton pregnancy Patients planned for elective cesarean section under spinal anesthesia
排除标准
- •Patients having a placental abnormality
- •Patients taking beta-blocker and vasodilator therapy
- •Patients with hypertensive disorder
研究组 & 干预措施
Phenylephrine 75
干预措施: Phenylephrine bolus 75 micrograms (Drug)
Phenylephrine 50
干预措施: Phenylephrine bolus 50 micrograms (Drug)
结局指标
主要结局
Number of Hypotensive episodes
时间窗: Number of hypotensive episodes occuring upto 10 minutes after administration of Oxytocin and Phenylephrine
Hypotension will be defined as fall in Mean Arterial pressure by more than 20% from baseline value.
次要结局
- Rescue Phenylephrine consumed(This will be the total amount of Phenylephrine consumed to treat the hypotensive episodes occuring upto 10 minutes after administration of Oxytocin and Phenylephrine)
研究者
Farwa Javed
Principal Investigator
Rawalpindi Medical College