Treatment of dentin hypersensitivity with 5% sodium fluoride varnish, low level laser therapy and associated application: randomized split-mouth clinical study

Not Applicable

• Conditions: Dentin Sensitivity; K08.8

• Registration Number: RBR-8yq5b8h
• Lead Sponsor: niversidade Estadual Paulista

Brief Summary

The presence of dentinal hypersensitivity is one of the most common complications after periodontal treatment. The use of desensitizing chemical substances such as fluorine and treatment with low-intensity lasers are some of the therapies instituted for the relief of painful symptoms. In order to reduce dentinal hypersensitivity, the present study evaluated the effect of a single application of therapies: 5% fluoride varnish (F), 780 nm GaAlAs laser (L) - dose of 52.5 J/cm2 (70mW and 30 seconds) or 2.1 J per point, for 6 seconds at 5 application points per element, the association of both (F+L) and control group (C). The 15 study participants received one therapy in each quadrant (split mouth). The 60 selected teeth were distributed among the groups using a randomized allocation sequence. The visual analogue scale (VAS: 0-10) was used to record hypersensitivity. Outcomes were evaluated at baseline, 24 hours, 30, 90 and 180 days after instituted therapy. Data were analyzed by ANOVA with complementation by Tukey test, significance level of 5%. The therapies (F), (L) and (F+L) demonstrated significant differences in the reduction of hypersensitivity from baseline for the periods of 30, 90 and 180 days. In the intergroup analysis, there was a statistically significant difference between (C) and (F) (p=0.0023) in the period of 180 days.

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-08-10
• Results First Posted: 2020-09-07
• Study Start: 2023-09-26
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Healthy volunteers; male or female aged between 20 and 65 years; with healthy periodontium; no periodontitis or gingivitis; presenting teeth without the presence of caries, cracks, fractures or extensive restorations; presenting teeth without premature contact; volunteers who have understood the study design; volunteers who have at least four sensitive teeth in their mouths, one in each oral quadrant; volunteers who have signed and agreed to the Informed Consent Form

Exclusion Criteria

Pregnant or breastfeeding women; subjects registered in another clinical trial; individuals who underwent professional treatment for hypersensitivity, or who used desensitizing products in the 3 months preceding the research period; history of maxillofacial cancer in the last 5 years; need for systemic treatment due to infection; patients who make chronic use of anti-inflammatory drugs, analgesics or psychotropic drugs; individuals who have allergies or who have some idiosyncratic response to any component of the product used in the research; patients who present parafunctional habits, eating disorders, gastric or emotional illness that is predisposed to dentin sensitivity; advanced medical or psychological illness; alcohol consumption or drug intoxication; hemorrhagic disease; systemic condition that is an etiological or predisposing factor for dentin sensitivity; diet with excessive exposure to acidic foods; individuals who underwent periodontal surgery or orthodontic treatment in the preceding 3 months; dental or periodontal pathologies, or defects that cause pain, such as caries, brackets”, and extensive fillings; teeth that serve as "abutments" or support for fixed or removable dentures, or that have crowns; teeth with restorations that extend to the test area (cervical); teeth with irreversible pulp inflammation.

Study & Design

• Study Type: Intervention
• Study Design: Not specified