The Ghent Psychotherapy Study (GPS)

Not Applicable

Completed

• Conditions: Major depressive disorder, conform criteria in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; Mental and Behavioural Disorders; Major depressive disorder

• Registration Number: ISRCTN17130982
• Lead Sponsor: Ghent University

Brief Summary

2017 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/28292331 protocol 2020 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31204837 qualitative results (added 18/06/2019) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37562373/ Primary outcome (added 14/08/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-02-25
• Study Completion: 2019-12-31
• Last Update Posted: 28 August 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Current inclusion criteria as of 01/10/2015:
1. Diagnosis of current major depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV), as assessed in the Structured Clinical Interview for DSM Disorders (SCID-I).
2. Hamilton Depression Rating Scale (HDRS) total score >14
3. Aged 18-65
4. Outpatient
5. Sufficient knowledge of the Dutch language
6. Dominance of either dependent or self-critical personality characteristics (prototype matching procedure by Werbart and Forsström: At least a score of 3/5 for one of the patterns and a minimum of 2 points difference with the score on the other personality pattern)
7. Patients on antidepressant medication can still meet inclusion criteria and can participate in the study if they are on a stable dose for at least four weeks. All medication use will be registered in detail throughout the procedure.

Previous inclusion criteria:
1. Diagnosed with major depressive disorder, according to the description in DSM-V
2. Aged >18 years old
3. Living in the Ghent region
4. Outpatient
5. Dutch speaking

Exclusion Criteria

Current exclusion criteria as of 01/10/2015:
1. Manifest psychotic symptoms or bipolar disorder
2. Acute suicidal risk
3. Current substance abuse /dependence (SCID)
4. Evidence of cognitive impairment that might prevent full participation in the treatments
5. Evidence of serious physical illness that strongly affects the depression or is causal for the depression
6. Other ongoing psychotherapeutic treatments

Previous exclusion criteria:
1. Acute psychotic episode
2. Acute suicidal tendency
3. Manifest substance abuse

Study & Design

• Study Type: Interventional
• Study Design: Not specified