Multi-slice CT Coronary Angiography in Patients With Stable Angina

Completed

• Conditions: Chronic Stable Angina

• Registration Number: NCT03963609
• Lead Sponsor: Benha University

Brief Summary

early identification of vulnerable plaques by remodeling index prior to rupture and development of acute event is of considerable importance especially by a reliable non-invasive method as CT coronary angiography.

Detailed Description

single-center, cross section, observational study included 150 patients with stable angina with normal resting ECG, negative markers, normal systolic function by 2D echocardiography (EF\>50%) and without regional wall motion abnormality at rest who were referred to MSCT evaluation of the coronary artery tree.

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2018-01-30
• Study Completion: 2018-03-01
• Status Verified: 2019-05
• Study First Submitted: 2019-05-21
• Study First Submitted QC: 2019-05-23
• Last Update Submitted: 2019-05-23
• Study First Posted: 2019-05-24
• Last Update Posted: 2019-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• first attack, low to intermediate risk stable angina
• normal resting ECG,
• negative markers
• normal systolic function by 2D echocardiography (EF>50%)
• without regional wall motion abnormality at rest who were referred to MSCT evaluation of the coronary artery tree.

Exclusion Criteria

• previous acute coronary syndrome or revascularization, those with renal impairment or dye hypersensitivity, patients with morbid obesity (BMI>40kg/m²), rhythm other than sinus rhythm inability to hold breath for 10sec to acquire the image lesions with heavy calcium score.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
remodeling of the coronary artery	2 years	to study the changes in wall of the arteries in patients with chronic stable angina early changes don't appear in coronary angiography as it occurs in the form of positive remodeling which can be detected by multisclice coronary angiography Remodeling index is defined as the ratio of the maximum vessel area (or diameter) to a normal reference vessel area (or diameter), and plaques are classified as having significant positive remodeling when the remodeling index is \>1.1