DAOIB for the Treatment of Mild Cognitive Impairment
Phase 2
Completed
- Conditions
- Mild Cognitive Impairment
- Registration Number
- NCT04736355
- Lead Sponsor
- Chang Gung Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 88
Inclusion Criteria
Inclusion Criteria:<br><br> - Clinical diagnosis of mild cognitive impairment<br><br> - MMSE between 17-26<br><br> - CDR 0.5<br><br>Exclusion Criteria:<br><br> - Hachinski Ischemic Score > 4<br><br> - Substance abuse/dependence<br><br> - Parkinson disease, epilepsy, dementia with psychotic features<br><br> - Major psychiatric disorders<br><br> - Major physical illnesses<br><br> - Severe visual or hearing impairment
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change from baseline in the Alzheimer's disease assessment scale - cognitive subscale at week 8, 16 and 24
- Secondary Outcome Measures
Name Time Method Change from baseline in Clinician's Interview-Based Impression of Change plus Caregiver Input score at week 8, 16 and 24;Change from baseline in Alzheimer's disease Cooperative Study scale for ADL in MCI (ADCS-MCI-ADL) score at week 8, 16 and 24;Change from baseline in Medical Outcomes Study Short-Form-36 (SF-36) score at week 8, 16 and 24;Change from baseline in the composite score of a battery of additional cognitive tests at week 8, 16 and 24