Cognitive Training for Treatment of Mild Cognitive Impairment in Parkinson's Disease (PD-MCI)

Not Applicable

• Conditions: G20; F06.7; Parkinson disease; Mild cognitive disorder

• Registration Number: DRKS00010186
• Lead Sponsor: Medizinische Psychologie Uniklinik Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-05-04
• Study Start: 2019-02-25
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• PD according to United Kingdom Brain Bank Criteria
• PD-MCI according to international research criteria (Litvan, Goldman et al. 2012)
• Disease duration = 3 years
• Stable medication 4 weeks prior to pretest
• Written informed consent

Exclusion Criteria

• Severe comorbidity with influence on medication or life expectancy or quality of life during the study (i.e. malignant disease with life expectancy < 6 months)
• Depression (BDI-II, exclusion beginning with moderate symptoms: cut off =20)
• Acute suicidality, ascertained anamnestically
• Marked daytime sleepiness, ascertained anamnestically
• Impuls controll disorder or dopamine dysregulation syndrom, ascertained anamnestically
• Acute psychosis (or psychotic episode 6 months prior to study inclusion)
• Acute medication with cholinesterase inhibitors or memantine
• Participation in another medication or training study within 2 months prior to study inclusion
• Deep brain stimualtion
• Pregnancy or breastfeeding

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
-California Verbal Learning Test<br>-Regensburger Verbal Fluency Test<br>-Modified Wisconsin Card Sorting Test/Tower of London Test<br>-Key Search Subtests<br>-Rey-Oesterrith Complex Figure Delayed Recall<br>-Backward Digit Span

Secondary Outcome Measures

Name	Time	Method
-Benton Line Orientation Test<br>-D2 Test of Attention & Endurance<br>-Wechsler Intelligence Scale for Adults (Letter-Number Sequencing)<br>-Boston Naming Test from the CERAD<br>-Speech Comprehension from the Aphasie Checkliste<br>-Rey-Oesterrith Complex Figure Copy<br>-Bayer ADL Scale<br>-PDQ-39<br>-Beck Depression Inventory II<br>-FEDA Questionnaire of Self-Perceived Deficits in Attention