European Home Mechanical Ventilation Registry

Terminated

• Conditions: Muscular Dystrophies; Amyotrophic Lateral Sclerosis; Congenital Central Hypoventilation Syndrome; Myopathies; Pulmonary Disease, Chronic Obstructive; Kyphoscoliosis; Myotonic Dystrophy; Spinal Cord Injury; Obesity Hypoventilation Syndrome; Duchenne Muscular Dystrophy

• Registration Number: NCT02315339
• Lead Sponsor: ResMed

Brief Summary

The European Home Mechanical Ventilation Registry (EHMVR) will enable a thorough evaluation of HMV by documenting the characteristics of HMV patients and their treatment. This will facilitate a prospective, observational study to identify the primary indications for HMV, describe patterns of HMV use in European countries, and characterize changes in the initiation and utilization of HMV over time. The registry will target all adult individuals who have an indication for HMV. In the EHMVR, patient data from routine clinical care will be documented using an electronic case report form (eCRF). The eCRF will record: patient demographic data; diagnostic information (including primary diagnosis, 6-minute walk time, the presence of depression, and quality of life); blood gases; ventilation treatment (including type of ventilator, modes and settings, interfaces used); follow-up data (including failure rates, side effects, technical issues). An initial Pilot Phase will be launched with the aim to enrol at least 200 patients over a 6-month period to determine the feasibility of the registry. Steering committee members and their institutions will be the main participants in the Pilot Phase. After completion of the Pilot Phase, the registry will be expanded across Europe with the goal of enrolling approximately 10,000 patients over 5 years.

Detailed Description

The data (baseline and follow-up) should be collected as part of routine clinical care. In clinical practice, after HMV initiation, the first control examination (follow-up number one) with nocturnal diagnostics should take place within the first 4-8 weeks. Annual follow-up is required, and it is recommended that subsequent control visits should be performed 1-2 times a year. Each patient will be included for 5 years (total duration of the registry).

Study Timeline

• Study Start: 2014-08
• Study First Submitted: 2014-10-06
• Study First Submitted QC: 2014-12-08
• Study First Posted: 2014-12-11
• Primary Completion: 2019-01
• Study Completion: 2019-01
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-08
• Last Update Posted: 2020-04-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Patients aged ≥18 years with an indication to receive HMV as part of routine clinical care
• Patient is able to fully understand the study information and is willing to give informed consent
• Patient, or the patient's legal guardian, signing the consent form

Exclusion Criteria

• No exclusion criteria have been defined because only data from routine clinical care are needed, plus a separate healthcare questionnaire

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determine the mortality rate and the number of hospital readmissions	every year (2014 to 2019), up to 5 years

Secondary Outcome Measures

Name	Time	Method
Determine the effects of home mechanical ventilation on health-related quality of life using the EQ-5D and the Severe Respiratory Insufficiency questionnaires quality of life	every year (2014 to 2019), up to 5 years

Trial Locations

Locations (1)

Lungen Klinik - Chefarzt Abt. Pneumologie Kliniken der StadtKölng GmbH; 🇩🇪 Cologne, Germany