Analysis of the Levels of HLADR+ Extracellular Vesicles in Women With Preeclampsia as a Early Potential Biomarker
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Levels of circulating HLA-DR+ extracellular vesicles
研究概览
简要总结
Analysis of the circulating levels of placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia.
详细描述
The aim of this study is to analyze the levels of circulating placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia to investigate the potential role of HLA-DR as early biomarker.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant Women
- •Aged > 18 years
排除标准
- •age < 18 years
- •women unable to give informed consent
- •infectious diseases
- •twin pregnancies
研究组 & 干预措施
"High risk"
Blood sampling from women with high risk to develop preeclampsia in the first, second and third trimester of pregnancy
干预措施: Blood samples for inflammatory markers (Other)
Low risk
Blood sampling from women with low risk to develop preeclampsia in the first, second and third trimester of pregnancy
干预措施: Blood samples for inflammatory markers (Other)
结局指标
主要结局
Levels of circulating HLA-DR+ extracellular vesicles
时间窗: During the first trimester of pregnancy (11-13 weeks +6 days of gestational age), the second trimester (19-22 weeks of gestation) and the third trimester (28-32 weeks of gestation) of pregnancy
Levels of circulating HLA-DR+ extracellular vesicles during pregnancy
次要结局
未报告次要终点