A comparative study on the effect and preference of Plenvu powd.(Polyethylene Glycol+Ascorbic acid) and ORA-FANG tab.(Oral sulfate solution)

Background: Proper bowel preparation during colonoscopy is important because it can affect the diagnostic accuracy of colonoscopy. Various low-capacity intestinal cleansers are being developed to improve the quality of intestinal cleansers and make them more convenient for patients to use. We aimed to check the efficacy and safety of low-dose intestinal cleansers. Methodology: A study conducted in a single center in a positive, random and single-blind manner. Patients who agreed to participate in the study will be randomly assigned to either the Oralsulfate solution (OSS) or 1L polyethyleneglycol (PEG)+ascorbate for the study. Based on the Boston Intestinal Preparation Scale (BBPS), the degree of intestines, patient satisfaction, and side effects were evaluated. Results: 171 patients were eventually analyzed. There was no significant difference (95.4% OSS; 96.4% 1LPEG + ascorbate; p=0.736) in the degree of adequate preparation (BBPS total score =6 and each segment score =2). Satisfaction with drug use was significantly higher in the OSS group (p<0.001), and the frequency of side effects was low in the OSS group (26.4% OSS; 50.0% 1L PEG+ascorbate; p<0.001). Side effects in both groups were minor and recovered without special treatment. Conclusion Both OSS and 1LPEG+ascorbate, which are low-capacity bowel cleaners, are effective in intestinal cleansing and no serious side effects have been reported.