Effect of Total Sleep Deprivation on Vascular Function

Not Applicable

Completed

• Conditions: Sleep Deprivation
• Interventions: Other: Exercise; Other: Supervised Total Sleep Deprivation

• Registration Number: NCT04535219
• Lead Sponsor: University of Florida

Brief Summary

Insufficient sleep is associated with an increased risk for cardiovascular disease. The causal mechanisms are currently unknown, but may include endothelial dysfunction. The purpose of this study is to examine the influence of sex and aging on the effects of total sleep deprivation on vascular function and whether exercise training attenuates these effects.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-08-24
• Study First Submitted QC: 2020-08-31
• Study First Posted: 2020-09-01
• Study Start: 2021-07-11
• Primary Completion: 2022-08-02
• Study Completion: 2022-08-02
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-25
• Last Update Posted: 2023-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 23

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Group C	Supervised Total Sleep Deprivation	Participants will have vascular function assessed following total sleep deprivation preceded by exercise
Group A	Supervised Total Sleep Deprivation	Participants will have vascular function assessed following total sleep deprivation
Group C	Exercise	Participants will have vascular function assessed following total sleep deprivation preceded by exercise

Primary Outcome Measures

Name	Time	Method
Endothelial function	through study completion, an average of 1 month	Endothelial function will be determined using brachial artery flow-mediated dilation via high resolution duplex ultrasonography. Reactive hyperemia will be produced by inflating a forearm cuff to \~250 mmHg for 5 minutes followed by rapid deflation.
Microvascular function	through study completion, an average of 1 month	Microvascular function will be assessed using the forearm blood flow response to submaximal handgrip exercise. Brachial artery blood flow and diameter will be assessed using Doppler ultrasound.

Secondary Outcome Measures

Name	Time	Method
Central arterial stiffness	through study completion, an average of 1 month	The SphygmoCor XCEL device will be used to measure carotid to femoral pulse wave velocity.
Central arterial hemodynamics	through study completion, an average of 1 month	The SphygmoCor XCEL device will be used to obtain central pulse wave analysis.

Trial Locations

Locations (1)

University of Florida; 🇺🇸 Gainesville, Florida, United States