Benefit of Ethanol Sclerotherapy of Endometriomas Before Ovarian Stimulation on Pregnancy Rates in IVF/ICSI

Not Applicable

Not yet recruiting

• Conditions: Infertile Women Undergoing IVF or ICSI

• Registration Number: NCT06878053
• Lead Sponsor: Poissy-Saint Germain Hospital

Brief Summary

Evaluation of progressive pregnancy rates (with an embryo with cardiac activity at 12 weeks), on a first attempt at IVF/ICSI (fresh and frozen embryo transfers) following the discovery of one or two endometrioma(s) of 30 to 80 mm, without a history of cystectomy, and comparison between the two groups: ethanol sclerotherapy and therapeutic abstention

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-10
• Study First Submitted QC: 2025-03-10
• Last Update Submitted: 2025-03-10
• Study First Posted: 2025-03-14
• Last Update Posted: 2025-03-14
• Study Start: 2025-06-01
• Primary Completion: 2029-06-01
• Study Completion: 2029-06-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 174

Inclusion Criteria

• Infertile women aged 18 to 43,
• Presenting one or 2 endometriotic cysts of 30 mm to 80 mm long axis, confirmed by ultrasound and/or pelvic MRI and without signs of atypia,
• With indication of IVF/ICSI, first IVF/ICSI after the discovery of endometriosis cyst(s),
• Having given their consent.

Exclusion Criteria

• A history of ovarian cystectomy,
• A non-homogeneous cyst that cannot be punctured (risk of incomplete aspiration),
• Complex adnexal image that cannot exclude an associated hematosalpinx (communicating hematosalpinx, tissue component),
• A recent tubo-ovarian infection,
• An active, untreated vaginal infection,
• Anticoagulant treatment at a therapeutic dose,
• All adult patients protected by law (under guardianship or curatorship),
• Problems understanding the French language,
• Participation in intervention research,
• All patients not affiliated to the social security system.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
cumulative rate of active pregnancies	12 weeks	Cumulative rate of active pregnancies defined by the presence of an embryo with cardiac activity at 12 weeks per IVF/ICSI cycle, including fresh and frozen embryo transfers in an IVF/ICSI attempt.