T-mult: exploring the impact of TMS induced virtual lesions on the multimodal brain network and cognitio
Recruiting
- Conditions
- not applicable10029305cognitief functioneren
- Registration Number
- NL-OMON53939
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
* Age between 20 and 65 years old
* Native Dutch speaker
* Able to provide written informed consent.
Exclusion Criteria
* Current diagnosis of neurological or psychiatric disease (including traumatic
head injury)
* Current and regular use of centrally acting drugs (recreational or
prescribed, including analgesics), including use of alcohol ~8 hours prior to
an appointment
* Presence of any contraindications for MRI, MEG, or TMS (including
resting-motor threshold >75% of maximum stimulator output or no useful
motor-evoked potential elicitable)
* Previous rTMS treatment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary effect of rTMS will be assessed through the change in performance<br /><br>on a neuropsychological test measuring executive functioning in the domain of<br /><br>executive functioning pre- and post-intervention. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondarily, changes in network organization will be characterised by<br /><br>(multimodal) neuroimaging pre- and post-treatment. Pre-treatment imaging will<br /><br>include magnetoencephalography (MEG), diffusion MRI (dMRI), task-based<br /><br>functional MRI (tbfMRI), and resting state fMRI (rsfMRI); post-treatment<br /><br>imaging will include only tbfMRI. </p><br>