Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty

• Conditions: Glaucoma
• Interventions: Procedure: Selective Laser Trabeculoplasty

• Registration Number: NCT01209975
• Lead Sponsor: University of Toronto

Brief Summary

The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.

Detailed Description

We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.

Study Timeline

• Study Start: 2008-11
• Study First Submitted: 2010-06-29
• Status Verified: 2010-09
• Study First Submitted QC: 2010-09-27
• Last Update Submitted: 2010-09-27
• Study First Posted: 2010-09-28
• Last Update Posted: 2010-09-28
• Primary Completion: 2011-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. Age 40-75 years (Male or Female)
2. Best corrected visual acuity of at least 20/40
3. No previous treatment for glaucoma
4. Ametropia less than ±6.0 DS and ±2.5 DC)
5. Non-smoker
6. No cardiovascular/respiratory disorders

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Exclusion Criteria

1. Past history of diabetes and cerebrovascular accident
2. Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion
3. Previous intraocular surgery
4. Ocular media opacities limiting the use of the imaging tests

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
untreated glaucoma patients	Selective Laser Trabeculoplasty	We will evaluate the blood flow before and after Selective Laser Trabeculoplasty in patients with primary open angel glaucoma.

Primary Outcome Measures

Name	Time	Method
blood flow	before and two-week after SLT	The Canon Laser Blood Flowmetry will be used to assess the retinal blood flow.

Secondary Outcome Measures

Name	Time	Method
Intraocuclar pressure	before and two-week after SLT	Intraocular pressure (IOP) will be measured by Goldmann applanation tonometry.

Trial Locations

Locations (1)

Toronto Western Hospital; 🇨🇦 Toronto, Ontario, Canada