Diameter Changes of Retinal Vessels During Hypoxia

Not Applicable

Completed

• Conditions: Diabetes Mellitus Type 1; Diabetic Maculopathy

• Registration Number: NCT01689090
• Lead Sponsor: University of Aarhus

Brief Summary

The primary objective is to study if an inhibition of nitric oxide and/or prostaglandins affect the diameter changes of retinal vessels observed during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-09-17
• Study First Submitted QC: 2012-09-17
• Study First Posted: 2012-09-20
• Study Start: 2012-11
• Status Verified: 2015-08
• Primary Completion: 2016-03
• Study Completion: 2016-03
• Last Update Submitted: 2018-10-11
• Last Update Posted: 2018-10-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• Diabetes type 1 without retinopathy
• Diabetic retinopathy

Exclusion Criteria

• Cardio-vascular disease
• Lung disease
• Pregnancy
• Previous ocular disease other than retinal branch vein occlusion
• Previous treatment with medications influencing on the intraocular pressure or the metabolism of nitric oxide or prostaglandins

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Diameter changes of retinal vessels	Examination day 1 and 2	Comparing the differences of diameter changes occuring during each of the interventions.

Trial Locations

Locations (1)

Department of Ophthalmology, Aarhus University Hospital; 🇩🇰 Aarhus, Denmark