NCT01308138CompletedNot Applicable
Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function
Norwegian University of Science and Technology2 sites in 1 country60 target enrollmentStarted: January 2011Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- Mitochondrial respiration
Study Overview
Brief Summary
The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Single (Investigator)
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients undergoing coronary heart surgery and heart transplantation
Exclusion Criteria
- •myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)
Outcomes
Primary Outcomes
Mitochondrial respiration
Time Frame: 1 hour
Oxygraph (Strathkelvin)
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (2)
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