NCT01308138已完成不适用
Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Mitochondrial respiration
研究概览
简要总结
The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing coronary heart surgery and heart transplantation
排除标准
- •myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)
研究组 & 干预措施
ExerciseTr
Experimental
干预措施: Exercise training (Behavioral)
Remote ischemic preconditioning group
Experimental
干预措施: remote ischemic preconditioning (Procedure)
Control patient group
No Intervention
结局指标
主要结局
Mitochondrial respiration
时间窗: 1 hour
Oxygraph (Strathkelvin)
次要结局
未报告次要终点
研究者
研究点 (1)
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