Is the duration of a nerve block prolonged by adding dexmedetomidine to the local anaesthetic among healthy volunteers.

Phase 1

• Conditions: Healthy volunteers (treatment intended to improve regional anesthesia for orthopedic surgery); MedDRA version: 19.1Level: LLTClassification code 10054711Term: Postoperative painSystem Organ Class: 100000004863; Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]

• Registration Number: EUCTR2016-004883-20-DK
• Lead Sponsor: Ole Mathiesen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12-08
• Last Update Posted: 6 November 2017

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Participants must meet all of the following criteria in order to be included in the trial:
•Age > 18 years
•Participants must understand the protocol fully and sign the written in-formed consent.
•ASA 1-2
•BMI > 18 to < 30
•For fertile women: safe contraceptives for the last month and a nega-tive urin HCG.

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 17
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 5

Exclusion Criteria

Participants meeting one or more of the following criteria cannot be in-cluded in the trial:
•Participants unable to cooperate in the trial.
•Participants unable to speak or read Danish
•Allergy to study medication.
•Alcohol consumption >21 units for men and >14 for women per week
•Daily intake of prescription painkillers within the last 4 weeks.
•Over the counter painkillers during the last 48 hours.
•Neuromuscular defects or wounds on the arms or hands preventing test performance.
•Diabetes Mellitus
•2. degree heart block
•Sick sinus node.
•For fertile women a positive urine HCG

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified