Incidence of colorectal lesions in first degree relatives of patients with hyperplastic polyposis syndrome (HPS)

Completed

Conditions: growth
tumor
10017990

Registration Number: NL-OMON32126

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 55

Inclusion Criteria

First-degree relatives (* 35 years of age or 5 years younger than the lowest incidence age) of patients under surveillance at the Endoscopy Department of the AMC with HPS, defined as:
1) *10 HPs found at colonoscopy, or
2) *5 HPs proximal to the sigmoid colon of which 2 are greater than 10mm in diameter, or
3) Any number of HPs occurring proximal to sigmoid colon in an individual who has a first-degree relative with hyperplastic polyposis

Exclusion Criteria

Exclusion criteria are 1) individuals who have undergone a colonoscopy in the past three years 2) individuals who have undergone a colectomy 3) severe co-morbidity and 4) age less than 35 years.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The occurrence, distribution and phenotype (gross morphology, number, size,<br /><br>shape) of polyps and CRC in first-degree relatives of patients with HPS will be<br /><br>assessed. Based on these findings an estimation of the risk of developing<br /><br>polyps/ HPS and CRC in this group can be made so as to define whether screening<br /><br>of this group is justified. In addition, the proportion of individuals that<br /><br>complied with the screening programme will be assessed as well as the<br /><br>proportion of non-compliers. In these two groups, socio-demographic data and<br /><br>potential predictors of compliance behaviour will be compared with the higher<br /><br>aim of designing an effective surveillance programme for these individuals. </p><br>

Secondary Outcome Measures