Comparison of desflurane(an inhalational anaesthetic) consumption in major surgery of the abdomen when used according to the brain activity vs. according to the amount that goes into the lungs, a randomized controlled trial
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/02/049808
- Lead Sponsor
- Institute of Liver and Biliary Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients, aged 18â??65 years
2. ASA physical status I, II or III
3.Elective major abdominal surgery with expected duration of more than 4 hours
Exclusion Criteria
1.Absence of consent
2.History of any disabling central nervous or cerebrovascular disease
3.Hypersensitivity to opioids
4.Substance abuse
5.Treatment with opioids or any psychoactive medication
6.Deviation from the standard care of anaesthesia
7.Not extubating on table
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The amount of desflurane used between MAC guided and entropy guided groups  <br/ ><br>Timepoint:  At the end of surgery <br/ ><br>
- Secondary Outcome Measures
Name Time Method cognitive dysfunction in the two groups using Mini Mental State Examination scaleTimepoint: 1 day after surgery;Emergence agitation between the groupsTimepoint: At the end of surgery;Heart rate and Blood pressure during surgeryTimepoint: every 10 minutes during surgery;Mean end-tidal desflurane concentration <br/ ><br>Timepoint: at the end of surgery;Recall between the groups using Michigan awareness scale <br/ ><br>Timepoint: 1 day after surgery;Time of awakening <br/ ><br>Timepoint: at the end of surgery