Acute Effects of Beet Juice Intake on the Vascular Function of Hypertensive Patients

Not Applicable

Completed

• Conditions: Hypertension
• Interventions: Dietary Supplement: Beetroot juice

• Registration Number: NCT04020796
• Lead Sponsor: Hospital Universitario Pedro Ernesto

Brief Summary

To assess the acute effects of only one dose of beet juice on hypertensive subjects treated with vascular endothelial function parameters, using the microvascular reactivity method.

Detailed Description

Systemic arterial hypertension is an established risk factor for cardiovascular disease (CVD). Among the main modifiable environmental factors of hypertension, the investigators highlight inadequate eating habits, such as low vegetable consumption. Clinical studies have shown that inorganic nitrate from beet juice intake has a protective effect against CVD due to reduced blood pressure, inhibition of platelet aggregation and prevention of endothelial dysfunction. However, there is still no consensus on its benefits of inorganic nitrate in vascular health. Associated with this, there are no previous studies in the literature that correlate the acute effects of inorganic nitrate intake on endothelial function assessed by microvascular reactivity through laser. The objective of the present study is to evaluate the acute effects (single dose) of inorganic nitrate, through the ingestion of beet juice, in the vascular parameters and endothelial function of treated hypertensive patients of both sexes.

Study Timeline

• Study Start: 2019-06-20
• Study First Submitted: 2019-06-28
• Study First Submitted QC: 2019-07-15
• Study First Posted: 2019-07-16
• Primary Completion: 2019-07-30
• Study Completion: 2019-08-15
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-27
• Last Update Posted: 2020-07-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Patients of both sexes
• Age between 40 and 70 years
• Previous diagnosis of primary systemic arterial hypertension
• Signed the Informed Consent Term.

Exclusion Criteria

• Secondary hypertension
• Systolic blood pressure greater than or equal to 180 mmHg or diastolic BP greater than or equal to 110 mmHg
• In use of beta-blockers
• Diabetes mellitus
• History of cancer
• Use of any dietary supplement
• Any serious life-threatening illness
• Cardiovascular diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Beetroot juice	Beetroot juice	Randomized cross-over trial. Thirty-seven hypertension, age 40-70 years were randomized to receive a 500ml volume of beetroot juice in a single moment.
Mineral water	Beetroot juice	Randomized cross-over trial. Thirty-seven hypertension, age 40-70 years were randomized to receive a 500ml volume of mineral water in a single moment.

Primary Outcome Measures

Name	Time	Method
Microvascular reactivity	150 minutes	A laser speckle contrast imaging system with a laser wavelength of 785 nm system will measure non-invasively real time cutaneous microvascular flow changes in the forearm. For the post occlusive reactive hyperemia test, arterial occlusion will be performed with suprasystolic pressure (50 mmHg above the systolic arterial pressure) using a sphygmomanometer applied to the arm of the subject over three minutes. Peak skin flow will be measured after pressure release.

Secondary Outcome Measures

Name	Time	Method
Central blood pressure	150 minutes	Central systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure before and after intervention and their potential effects on changes in subendocardial viability ratio and ejection duration after intervention with beetroot juice and water.

Trial Locations

Locations (1)

Samanta de Souza Mattos; 🇧🇷 Rio de Janeiro, RJ, Brazil