People Living With HIV/AIDS, Nitrate, Endotelial Function, Arterial Stiffness and Skeletal Muscle Oxygenation

Not Applicable

Completed

• Conditions: HIV/AIDS
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: Beetroot Juice

• Registration Number: NCT03485248
• Lead Sponsor: Universidade Federal do Rio de Janeiro

Brief Summary

Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality. However, it is responsible for intensifying complications triggered by the chronic inflammatory state associated with virus infection, such as cardiovascular diseases. The current study evaluated effects of single dose (140mL) of Beetroot Juice (BJ) on macro and microvascular endothelial function in HIV-1-patients undergoing antiretroviral terapy, once BJ was shown to be effective in improving these physiological parameters in uninfected individuals.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-18
• Study First Submitted: 2018-03-13
• Study First Submitted QC: 2018-03-25
• Study First Posted: 2018-04-02
• Primary Completion: 2018-08-15
• Study Completion: 2018-11-28
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-25
• Last Update Posted: 2019-04-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• HIV infection for a period of 1 year or greater
• Regular use of high-potency antiretroviral therapy for at least one year

Exclusion Criteria

• Individuals who are physically active
• Individuals who are allergic to some component of beet
• Individuals who use nutritional and / or pharmacological ergogenics
• Individuals receiving antibiotics or who have osteomioarticular problems

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo beet juice (Nitrate depleted)	Placebo	Beetroot juice nitrate depleted
Beetroot juice	Beetroot Juice	Beetroot Juice cotaining on average 9mmol of nitrate per dose

Primary Outcome Measures

Name	Time	Method
Skeletal Muscle Oxygenation	Baseline and approximately after 150 minutes of beetroot juice consumption	Changes in skeletal muscle oxygenation in response to exercise will be evaluated by using a near-infrared spectroscopy device.
Brachial artery flow-mediated dilatation	Baseline and approximately after 150 minutes of beetroot juice consumption	The brachial artery flow-mediated dilation will be evaluated by using an ultrasound device.

Secondary Outcome Measures

Name	Time	Method
Urinary nitrate concentrations	Baseline and approximately 30, 90, and 150 minutes after beetroot juice consumption	Analysis of nitrate in urine will be performed by using high-performance liquid chromatography system.

Trial Locations

Locations (1)

DST / AIDS and Viral Hepatitis Program of Macaé; 🇧🇷 Macaé, Rio De Janeiro, Brazil