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临床试验/NCT05695079
NCT05695079已完成不适用

Evaluating the Efficacy of Pedestal Fans for Limiting Heat Strain in Elderly Adults During Extreme Heat Events

University of Ottawa2 个研究点 分布在 1 个国家目标入组 19 人开始时间: 2022年12月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
19
试验地点
2
主要终点
Core temperature (peak)

研究概览

简要总结

With the increasing regularity and intensity of hot weather and heat waves, there is an urgent need to develop heat-alleviation strategies able to provide targeted protection for heat-vulnerable older adults. While air-conditioning provides the most effective protection from extreme heat, it is inaccessible for many individuals. Air-conditioning is also energy intensive, which can strain the electrical grid and, depending on the source of electricity generation, contribute to increasing green house gas emissions. For these reasons, recent guidance has advocated the use of electric fans as a simple and sustainable alternative to air-conditioning. To date, however, only one study has assessed the efficacy of fan use in older adults and demonstrated that fans accelerate increases in body temperature and heart rate in a short-duration (~2 hours) resting exposure to 42°C with increasing ambient humidity from 30-70%. While subsequent modelling has suggested that fans can improve heat loss via sweat evaporation in healthy older adults at air temperatures up to 38°C, there is currently no empirical data to support these claims. Further, that work assumed older adults were seated in front of a pedestal fan generating an airflow of 3·5-4·5 m/s at the front of the body. This airflow cannot be attained by most marketed pedestal fans. Studies are therefore needed to evaluate the efficacy of fans for preventing hyperthermia and the associated physiological burden in older adults in air temperatures below 38°C and determine whether the cooling effect of fans, if any, is evident at lower rates of airflow.

To address these knowledge gaps, this randomized crossover trial will evaluate body core temperature, cardiovascular strain, dehydration, and thermal comfort in adults aged 65-85 years exposed for 8 hours to conditions experienced during hot weather and heat waves in North America simulated using a climate chamber (36°C, 45% relative humidity). Each participant will complete three randomized exposures that will differ only in the airflow generated at the front of the body via an electric pedestal fan: no airflow (control), low airflow (~2 m/s), and high airflow (~4 m/s). While participants will spend most of the 8-hour exposure seated in front of the fan, they will also complete 4 x 10 min periods of 'activities of daily living' (~2-2.5 METS, light stepping) at ~2 hour intervals to more accurately reflect activity patterns in the home.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Double (Participant, Outcomes Assessor)

盲法说明

Participants will be informed of the study interventions before providing informed consent but will be masked to the order of the arms until exposure (i.e., participants will not know the fan conditions). Data will be blinded prior to analysis.

入排标准

年龄范围
65 Years 至 85 Years(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Male or female adults.
  • Aged 65-85 years.
  • Non-smoking.
  • English or French speaking.
  • Ability to provide informed consent.

排除标准

  • Physical restriction (e.g., due to disease: intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).
  • Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable (e.g., medications increasing risk of heat-related illness; beta blockers, anticholinergics, etc.)
  • Cardiac abnormalities identified via 12-lead ECG during an incremental exercise test to volitional fatigue (performed for all participants).
  • Peak aerobic capacity (VO2peak), as measured during an incremental exercise test to volitional fatigue, exceeding the 50th percentile of age- and sex-specific normative values published by the American College of Sports Medicine (ACSM).

结局指标

主要结局

Core temperature (peak)

时间窗: End of heat exposure (hour 8)

Peak rectal temperature (15 min average) during exposure. Rectal temperature is measured continuously throughout each simulated heat wave.

次要结局

  • Heart rate variability: RMSSD (end-exposure)(End of heat exposure (hour 8))
  • Air movement scale (end-exposure)(End of heat exposure (hour 8))
  • Heart rate (end-exposure)(End of heat exposure (hour 8))
  • Fluid consumption(End of heat exposure (hour 8))
  • Fluid loss(End of heat exposure (hour 8))
  • Core temperature (end-exposure)(End of heat exposure (hour 8))
  • Heart rate variability: SDNN (end-exposure)(End of heat exposure (hour 8))
  • Change in plasma volume(End of heat exposure (hour 8))
  • Thermal comfort scale (end-exposure)(End of heat exposure (hour 8))
  • Core temperature (AUC)(End of heat exposure (hour 8))
  • Systolic blood pressure (end-exposure)(End of heat exposure (hour 8))
  • Diastolic blood pressure (end-exposure)(End of heat exposure (hour 8))
  • Heart rate (peak)(End of heat exposure (hour 8))
  • Heart rate (AUC)(End of heat exposure (hour 8))
  • Rate pressure product (end-exposure)(End of heat exposure (hour 8))

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Glen P. Kenny

Full Professor, University Research Chair

University of Ottawa

研究点 (2)

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