相关临床试验
121
11 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1848
进行中（未招募）
2
1.6%
已完成
58
47.9%
Enrolling By Invitation
1
0.8%
尚未招募
8
6.6%
招募中
25
20.7%
暂停
1
0.8%
终止
1
0.8%
Unknown
21
17.4%
撤回
4
3.3%
暂无批准数据
- Researchers at the Rocky Mountain Biological Laboratory launched "OnlyMarms," a G-rated OnlyFans account, to fund their long-running yellow-bellied marmot study after federal science funding cuts threatened termination. - A marmot-themed "meme coin" named $OnlyMarms, created by outside supporters on the Solana blockchain, raised more than $88,000 in two weeks, pushing total funding past $100,000. - The combined OnlyFans and cryptocurrency funding will sustain the project for another year, though researchers acknowledge it is not an adequate substitute for standard government funding. - The 60-year study, started by Kenneth Armitage in 1962, documents climate-driven changes, including increased marmot body mass and a record die-off linked to lack of snow cover.
- A systematic review of five randomized controlled trials found that creatine as an add-on therapy showed benefit in two trials involving women with major depressive disorder but no effect in three other trials. - In one positive trial, 5 grams of daily creatine added to escitalopram produced a large effect size (Cohen's d of 1.13) on the Hamilton Depression Rating Scale over eight weeks. - Two participants with bipolar disorder who received creatine developed hypomania or mania, signaling potential risks depending on underlying diagnosis. - Researchers emphasize that current evidence is insufficient to change clinical practice and call for larger, longer, and more rigorous trials.
- The COBRRA trial found that apixaban reduced bleeding risk by more than half compared to rivaroxaban in 2,760 patients with acute venous thromboembolism over three months. - Clinically relevant bleeding occurred in 3.3% of apixaban patients versus 7.1% of rivaroxaban patients, with no significant difference in blood clot recurrence rates. - Despite higher medication adherence with rivaroxaban (75.1% vs 65.7%), the safety advantage of apixaban remained consistent across the international study. - The findings provide the first head-to-head comparison of these commonly prescribed anticoagulants and may influence clinical practice guidelines for venous thrombosis treatment.
- People diagnosed with cannabis use disorder (CUD) face nearly triple the risk of death over five years compared to the general population, with a tenfold increase in suicide risk, according to a large Canadian study. - Since Canada's 2018 cannabis legalization, cases of psychosis and schizophrenia linked to CUD have significantly increased, with young adults aged 19-24 most vulnerable to these effects. - Medical marijuana users show equal or higher addiction rates than recreational users, with researchers finding no evidence that medical cannabis carries reduced addiction risk.
- Emergency room patients treated for psychedelic use face a 2.6-fold higher risk of death within five years compared to the general population, with particularly elevated risks for suicide, cancer, and overdose. - Individuals requiring emergency care after hallucinogen use demonstrate a 21-fold increased risk of developing schizophrenia compared to the general population, even after controlling for pre-existing conditions. - Annual rates of emergency room visits involving hallucinogens increased by 86% between 2014 and 2021, highlighting growing concerns as recreational psychedelic use continues to rise.
- A clinical trial demonstrates that removing approximately 10% of a patient's blood before liver surgery significantly reduces the need for blood transfusions during the procedure. - Hypovolemic phlebotomy lowers blood pressure in the liver, decreasing blood loss and the risk of requiring a transfusion, potentially benefiting one in eleven patients. - The study, involving 446 participants, found that only 8% of patients undergoing blood draw required transfusion, compared to 16% in the control group. - This safe, inexpensive technique, costing only around $20 in materials, could save healthcare systems money compared to the $350 cost of a blood transfusion in Canada.
• Women undergoing chemotherapy for breast cancer reported improved cognitive function when participating in an aerobic exercise program, according to the ACTIVATE trial. • The study found that patients who started aerobic exercise alongside chemotherapy experienced better self-reported mental abilities compared to those receiving standard care alone. • Objective neuropsychological testing showed similar cognitive performance between the exercise and standard care groups, but exercise still improved quality of life. • Researchers suggest integrating exercise assessment and referral into routine cancer care to support both physical and mental health during and after treatment.
- A recent study indicates that edaravone, an existing ALS drug, can be repurposed to target brain tumor stem cells (BTSCs) in glioblastoma. - Edaravone inhibits the self-renewal and proliferation of BTSCs, which are responsible for tumor growth and resistance to current therapies. - Combining edaravone with ionizing radiation enhances the effectiveness of radiation, leading to delayed tumor growth and extended survival in animal models. - Researchers are optimizing edaravone dosage to facilitate clinical trials, potentially offering a new therapeutic option for glioblastoma patients.
