Protein absorption in critical illness

Not Applicable

Completed

• Conditions: Critically ill; Protein absorption; Diet and Nutrition - Other diet and nutrition disorders; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12616001652460
• Lead Sponsor: Royal Adelaide Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-11-30
• Study Completion: 2020-02-17
• Last Update Posted: 30 November 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

ICU patients:
*Adults (greater than or equal to 18 years of age)
*Admitted to the Royal Adelaide Hospital Intensive Care Unit
*Mechanically ventilated
*Suitable for enteral feeding
*Arterial line insitu
*Consent obtained

Healthy volunteer arm:
*Adults (greater than or equal to 18 years of age)

Exclusion Criteria

ICU patients:
*Recent upper abdominal surgery
*Vegan
*Lactose intolerance
*Any order to withhold active treatment
*Jehovah’s Witness
*For muscle biopsy: Bleeding diathesis (INR > 1.5; APTT > 50) including those receiving anticoagulants (other than low dose for DVT prophylaxis) and anti-platelet agents

Healthy volunteer arm:
*Significant illness
*Smokers (cigarettes/cigars/marijuana)
*Intake of >2 standard drinks on >5 days per week
*Intake of >4 cups of caffeinated drinks per day
*Intake of any illicit substance
*Vegan
*Lactose intolerance
*Use of prescribed or non-prescribed medications that may affect gastrointestinal function
*Significant gastrointestinal symptoms, disease or surgery (apart from uncomplicated appendectomy)
*For muscle biopsy: Bleeding diathesis (INR > 1.5; APTT > 50) including those receiving anticoagulants (other than low dose for DVT prophylaxis) and anti-platelet agents

Study & Design

• Study Type: Observational
• Study Design: Not specified