Protein and Energy Interactions in Critically Ill Childre

Completed

• Conditions: diabetes type 2; Insuline resistance; 10018424; 10037008

• Registration Number: NL-OMON33362
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Diagnosis of SIRS, sepsis or septic shock
Indwelling central venous access placed for clinical purpose.
total parenteral nutritional support for at least 2 days.

Exclusion Criteria

Patients with metabolic diseases i.e.: urea cycle disorders, cystinuria and insulin dependent diabetes mellitus
Patients with hepatic or renal failure
Enteral feeds providing more than 20% of total daily protein and energy intake based on age and weight.
Insulin therapy prior to the start of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Whole body protein balance at baseline and during a HEC with standard and high<br /><br>protein intake<br /><br>in critically ill children.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Insulin resistance with standard and high protein intake in critically ill<br /><br>children<br /><br>- Glucose metabolism at baseline and during a HEC with standard and high<br /><br>protein intake in critically ill<br /><br>children.<br /><br>- Lipid metabolism at baseline and during a HEC with standard and high protein<br /><br>intake in critically ill<br /><br>children.</p><br>