Energy Requirements of Critically Ill Obese Patients: Does Goal Directed Nutrition Using Indirect Calorimetry Improve Energy Delivery?

Not Applicable

• Conditions: Critical illness; Obesity; Diet and Nutrition - Obesity

• Registration Number: ACTRN12614001285640
• Lead Sponsor: A/Prof Ibolya Nyulasi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-12-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

BMI greater than or equal to 30m2/Kg
- Within 72 hours of ICU admission at the time of enrolment
- Mechanically ventilated at the time of enrolment and expected to remain ventilated until the day after tomorrow
- At least 18 years of age

Exclusion Criteria

- There is a long term technical contraindication to a IC measurement
- Are not expected to commence nutrition therapy in next 24hrs for any reason
- Death is imminent or deemed highly likely in the next 96 hours.
- There is a current treatment limitation in place or the patient is unlikely to survive to 6 months due to underlying illness
- Are known to be pregnant
- The treating clinician does not believe the study to be in the best interest of the patient
- Patient is not expected to continue with nutrition therapy for > 72 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome of this study is daily delivered energy as a proportion of measured energy expenditure (using indirect calorimetry) to determine adequacy of energy provision, and compare groups with respect to under and over feeding.[Daily energy intake over 14 days]

Secondary Outcome Measures

Name	Time	Method
Energy expenditure (using indirect calorimetry) at four timepoints:within 24 hours enrolment & twice weekly until day 14 (or until extubation)[14 days (or until extubation)];Daily protein intake assessed as grams of protein received divided by weight in kilograms.<br>[14 days (or until extubation)];Duration of mechanical ventilation (number of days from intubation to extubation).[Until extubation (censored at 60 days)];Length of ICU admission[Until ICU discharge (censored at 60 days)];Length of hospital admission[Until hospital discharge (censored at 60 days)];Survival[60 days];Hand grip strength (measured using a hand grip strength dynamometer)[ICU and hospital discharge (censored at 60 days)];Highest level of function scale (using ICU mobility scale)[ICU and hospital discharge (censored at 60 days)];Quality of life questionnaire (EQ-5D)[At hospital discharge (censored at 60 days)]