Intestinal Flora Sequencing for Nasopharyngeal Carcinoma

Completed

• Conditions: Nasopharyngeal Carcinoma

• Registration Number: NCT04094545
• Lead Sponsor: The Third Xiangya Hospital of Central South University

Brief Summary

This study investigated the correlation between the changes in the intestinal flora and NPC by an examination of the intestinal flora and multiple clinical indicators of the blood of 8 carefully screened patients of familial NPC, 24 patients of sporadic NPC and 27 healthy controls and a comparison of the differences in their intestinal flora structures and biological functions. By analyzing the function of the intestinal floras of NPC patients, we aimed to provide a better biological marker for patients with familial and sporadic NPC and constructed a disease prediction model for high-risk populations.

Detailed Description

Nasopharyngeal carcinoma (NPC) is a malignant nasopharyngeal disease with a complicated etiology that occurs mostly in southern China. Intestinal flora imbalance is believed to be associated with a variety of organ malignancies. Currently, the relationship between intestinal flora and NPC is not clear, although many studies have shown that intestinal flora can be used as a biomarker for many cancers and to predict cancer.

To compare the differences in intestinal flora compositions and biological functions among patients with familial NPC (NPC_F), patients with sporadic NPC (NPC_S) and healthy controls (NOR), we compared the intestinal flora DNA sequencing and hematological testing results between every two groups using bioinformatic methods.

Study Timeline

• Study Start: 2018-08-01
• Status Verified: 2018-09
• Primary Completion: 2018-12-31
• Study Completion: 2019-05-30
• Study First Submitted: 2019-09-17
• Study First Submitted QC: 2019-09-17
• Last Update Submitted: 2019-09-17
• Study First Posted: 2019-09-19
• Last Update Posted: 2019-09-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 568

Inclusion Criteria

• NPC patients with a first degree family history of NPC
• NPC patients without any kind of tumor family history

Exclusion Criteria

• Informed refusal.
• Lack of necessary tests and patient test information is not detailed

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
family NPC patients	through study completion, an average of 1 year	NPC patients with a first degree NPC family history
sporadic NPC patients	through study completion, an average of 1 year	NPC patients without any tumor family history

Trial Locations

Locations (1)

the Third Xiangya Hospital of Central South University; 🇨🇳 Changsha, Hunan, China