The study to compare two different dose of norepinephrine based on weight of the patient for preventing fall in blood pressure after spinal anaesthesia in patients undergoing cesarean section

Phase 2/3

Completed

• Conditions: Pregnancy, childbirth and the puerperium,

• Registration Number: CTRI/2024/02/062991
• Lead Sponsor: SK Saif ali

Brief Summary

Hypotension is the most common complication seen in patients undergoing Caesarean section under spinal anaesthesia.Norepinephrine infusion has been suggested as an effective method for preventing hypotension during spinal anaesthesia for elective Caesarean section. Norepinephrine  associated with less propensity to reduce heart rate and cardiac output owing to its mild beta adrenergic agonist effects.our study compares norepinephrine infusion with two different combinations in elective Caesarean section under spinal anaesthesia

Detailed Description

Not available

Study Timeline

• Study Start: 2024-02-21
• Study Completion: 2024-05-24
• Last Update Posted: 2024-07-26

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 170

Inclusion Criteria

1)full term women undergoing elective cesarean section 2) ASA class II 3)age between 18-35 years.

Exclusion Criteria

1. patients refusal 2)hypertensive disorders 3)cardiac diseases 4)allergy to local anaesthetics 5)obstretic complications (antepartum hemorrhage,placenta privea,placental abruption) 6)coagulopathy,sepsis,hepatic or renal failure.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)Doses of rescue bolus of phenylephrine 20 mcg	Incidence of hypotension is assessed immediately after spinal anaesthesia measurement of blood pressure every 1 minute after spinal till the delivery of baby and the amount of PHENYLEPHERINE boluses used during the intraoperative period.
2)access incidence of hypotension in both groups	Incidence of hypotension is assessed immediately after spinal anaesthesia measurement of blood pressure every 1 minute after spinal till the delivery of baby and the amount of PHENYLEPHERINE boluses used during the intraoperative period.

Secondary Outcome Measures

Name	Time	Method
1)intraoperative blood pressure(systolic and diastolic h	Pressure)

Trial Locations

Locations (1)

Sri Ramachandra institute of higher education and research; 🇮🇳 Chennai, TAMIL NADU, India

Sri Ramachandra institute of higher education and research

🇮🇳Chennai, TAMIL NADU, India

Dr SK Saif ali

Principal investigator

8895706873

saifali669@gmail.com