Prevalence of drug-resistant tuberculosis in Sinaloa Mexico

Not Applicable

Completed

Conditions: Prevalence of drug-resistant Mycobacterium tuberculosis (DR-MTB) in HIV and diabetic patients
Infections and Infestations

Registration Number: ISRCTN18957388

Lead Sponsor: Autonomous University of Sinaloa

Brief Summary: 2024 Results article in https://doi.org/10.3390/tropicalmed9040089 (added 25/04/2024)

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 391

Inclusion Criteria

1. Aged between 18-85 years old
2. Populations with HIV or T2DM
3. Positive diagnosis in the state of Sinaloa in the period 2019-2021 of pulmonary Mycobacterium tuberculosis

Exclusion Criteria

1. Aged 17 years old and under
2. Aged 86 years old and over
3. Extrapulmonary Mycobacterium tuberculosis diagnosis
4. Diagnosis in the other States of México
5. Diagnosis prior to 2019 or after 15 February 2022
6. Clinical cases HIV-TB and T2DM-TB not diagnosed with GeneXpert technique

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of rifampicin drug-resistant Mycobacterium tuberculosis, determined by a positive diagnosis using the GeneXpert MTB/RIF Dx System test version 4.7, recorded in the SINAVE database between January 2019 and February 2022

Secondary Outcome Measures

Name	Time	Method
Recorded in the SINAVE database between January 2019 and February 2022:<br>1. Prevalence of TB/HIV, the following information will be used: p= number of events with the disease/total recorded events<br>2. Prevalence of TB/T2DM, the following information will be used: p= number of events with the disease/total recorded events<br>3. Prevalence of TB/T2DM drug resistance to rifampicin, the following information will be used: p= number of events with the disease/total recorded events<br>4. The correlation between suffering from the disease, HIV or T2DM with the presence of DR-TB, the prevalence ratio will be obtained and subsequently the prevalence odds ratio<br>5. Sociodemographic variables such as sex, age, weight, disease other than HIV or T2DM location of the disease, institution that provides care, the form of diagnosis, smoking, alcoholism and drug addiction will be recorded from the clinical history obtained from the SINAVE database