ARTERIAL STIFFNESS IN PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY

Recruiting

Conditions: Duchenne muscular dystrophy
10019280
10028302
10029317

Registration Number: NL-OMON54937

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 56

Inclusion Criteria

Inclusion criteria for DMD patients cross sectional part:
- Age between 4-15 years
- Confirmation of the diagnosis of Duchenne Muscular Dystrophy by DNA mutation
or muscle biopsy.
- Who visit the DMD-out patient clinical of the LUMC for their annual visit

Additional inclusion criteria for DMD patients longitudinal part:
- Initiation of ACEi therapy is proposed by pediatric cardiologist based on
clinical decision making/the Duchenne Care Considerations.

Healthy controls:
4-12 years

Exclusion Criteria

- Previous exposure to cardiac medication, including ACE inhibitors (history or
current use)
- Unable to lie in supine position for echocardiography
- Impossibility to measure jugulum-symphysis distance

Healthy controls:
Any sign of history of cardiovascular disease
- Previous or current exposure to cardiac medication
- Unable to lie in supine position for PWV measurement
- Impossibility to measure jugulum-symphysis distance
- Any muscle disease

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Arterial stiffness of pediatric DMD patients compared to healthy controls, as<br /><br>non-invasively assessed with PWV measurement with the Arteriograph. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. To investigate whether treatment with ACEi influences arterial stiffness,<br /><br>measured by PWV, over time in DMD patients<br /><br>2. Explore the (longitudinal) relation between arterial stiffness and cardiac<br /><br>function in DMD patients<br /><br>3. Assess the accuracy of PWV measurement using the Arteriograph versus PWV<br /><br>measured by cardiac MRI in DMD patients</p><br>