NCT04676958已完成不适用
Effects of Vitamin K2 on Recovery From Muscle Damaging Exercise in Young and Older Adults
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 3
- 主要终点
- Change in post exercise recovery of muscle strength
研究概览
简要总结
The aim of the current study, therefore, is to investigate the effects of vitamin K2 supplementation on the physiological responses to an acute bout of resistance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant is able and willing to sign the Informed Consent From
- •No plans to change lifestyle (activity and nutrition) during the study period
- •Older group (n=40): 65 years of age or older.
- •Younger group (n=40): Aged 18-40 years
排除标准
- •Not currently, or in the last year, participating in more than 1h per week of vigorous aerobic physical activity or any resistance exercise
- •BMI > 30 kg/m2
- •severe cardiovascular disease
- •seizure disorders
- •liver disease
- •uncontrolled hypertension (>150/90mmHg at baseline measurement)
- •cancer or cancer that has been in remission <5 years
- •ambulatory impairments which would limit ability to perform assessments of muscle function
- •currently taking Vitamin K2 supplements
- •currently taking Vitamin K antagonists/anticoagulants (e.g. warfarin)
- •current smoking
- •history of drug abuse
- •taking medication known to affect muscle (e.g. steroids).
结局指标
主要结局
Change in post exercise recovery of muscle strength
时间窗: Change from baseline to 12 weeks
Muscle strength (MVC) of the knee extensor muscles will be measured before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise
次要结局
- Change in pain free range of motion during knee extension exercise(Change from baseline to 12 weeks)
- Change in post exercise recovery of sEMG activity(Change from baseline to 12 weeks)
- Change in post exercise interleukin-6(Change from baseline to 12 weeks)
- Change in Carboxylated Osteocalcin levels(Change from baseline to 12 weeks)
- Change in post exercise recovery of functional abilities(Change from baseline to 12 weeks)
- Change in post exercise peroxiredoxin 3 redox state(Change from baseline to 12 weeks)
- Change in vitamin K levels(Change from baseline to 12 weeks)
- Change in uncarboxylated Osteocalcin levels(Change from baseline to 12 weeks)
- Change in dephosphorylated-uncarboxylated matrix gla-protein levels(Change from baseline to 12 weeks)
- Change in carboxylated matrix gla-protein levels(Change from baseline to 12 weeks)
- Change in post exercise F2 isoprostanes(Change from baseline to 12 weeks)
研究者
Stuart Gray
Senior Lecturer
University of Glasgow
研究点 (3)
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