Study on Prediction of Left Ventricular Remodeling Using ST2

Completed

• Conditions: Acute Coronary Syndrome

• Registration Number: NCT03841214
• Lead Sponsor: Keimyung University Dongsan Medical Center

Brief Summary

Patients who underwent percutaneous coronary intervention after diagnosis of acute coronary syndrome should be enrolled in the study and follow - up.

Detailed Description

Obtain written consent for patients who meet all of the selection criteria and who do not meet the exclusion criteria.

ACS(Acute Coronary Syndrome) patients with LV systolic dysfunction(LVEF\<50%) on TTE test who underwent successful PCI. At that time, patient proceed with the Baseline blood test(ST2) in hospital.

And then, Medical therapy for 3 months later patient proceed with the Follow-up blood test(ST2) and TTE in OPD.

Study Timeline

• Study First Submitted: 2019-02-12
• Study First Submitted QC: 2019-02-12
• Study First Posted: 2019-02-15
• Study Start: 2019-02-25
• Status Verified: 2020-06
• Primary Completion: 2021-03-31
• Study Completion: 2021-06-30
• Last Update Submitted: 2022-03-29
• Last Update Posted: 2022-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 114

Inclusion Criteria

• Subjects aged 19 or older
• Patients with acute coronary syndrome who underwent successful percutaneous coronary intervention
• Patients with left ventricular ejection fraction less than 50% on transthoracic echocardiography
• Patients who voluntarily agreed to participate in the study

Exclusion Criteria

• Failure to obtain TIMI 3 flow after procedure
• If the remaining life span is less than one year
• Women who are breastfeeding or plan to become pregnant or are planning to become pregnant during the study period

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ST2 and LV end-diastolic volume index	3 months	the correlation between changes of ST2 and LV end-diastolic volume index

Secondary Outcome Measures

Name	Time	Method
ST2 and LV ejection fraction	3 months	the correlation between changes of ST2 and LV ejection fraction
ST2 and E over e' ratio	3 months	the correlation between changes of ST2 and E over e' ratio
ST2 and LV wall motion score	3 months	the correlation between changes of ST2 and LV wall motion score

Trial Locations

Locations (1)

Keimyung University Dongsan Hospital; 🇰🇷 Daegu, Dalseogu, Korea, Republic of