Effect of supplementation in treatment of Coronary Heart Disease

Phase 3

Conditions: Coronary Heart Disease.
Ischaemic heart disease (chronic) NOS
I25.9

Registration Number: IRCT201503175623N40

Lead Sponsor: Kashan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

Subjects aged 40-85 years
Diagnosed with type 2 diabetes and CVD

Exclusion Criteria

Intake of folate supplements within the last 3 months
Acute myocardial infarction within the past 3 months
Cardiac surgery within the past 3 months
Renal or liver failure

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Carotid intima media thickness. Timepoint: Baseline and End-of-trial. Method of measurement: Sonography.

Secondary Outcome Measures

Name	Time	Method
Fasting plasma glucose. Timepoint: Baseline and End-of-trial. Method of measurement: Enzymatic.;Insulin. Timepoint: Baseline and End-of-trial. Method of measurement: Elisa.;Cholesterol. Timepoint: Baseline and End-of-trial. Method of measurement: Enzymatic.;Triglyceride. Timepoint: Baseline and End-of-trial. Method of measurement: Enzymatic.;Insulin resistance. Timepoint: Baseline and End-of-trial. Method of measurement: Elisa kit.;HDL-cholesterol. Timepoint: Baseline and End-of-trial. Method of measurement: Enzymatic.;Hs-CRP. Timepoint: Baseline and End-of-trial. Method of measurement: Elisa kit.;Nitric oxide. Timepoint: Baseline and End-of-trial. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: Baseline and End-of-trial. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: Baseline and End-of-trial. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: Baseline and End-of-trial. Method of measurement: Spectrophotometry.