Folic Acid and Carotid Intima-media Thickness: a 3-year randomised controlled trial (RCT) examining the effects of folic acid supplementation on vascular disease

Not Applicable

Completed

• Conditions: Vascular disease; Circulatory System

• Registration Number: ISRCTN33564325
• Lead Sponsor: Wageningen Centre for Food Sciences (WCFS) (The Netherlands)

Brief Summary

2007 Results article in http://www.ncbi.nlm.nih.gov/pubmed/17200216 2007 Results article in http://www.ncbi.nlm.nih.gov/pubmed/17240287 2011 Results article in https://pubmed.ncbi.nlm.nih.gov/21430116/ (added 23/05/2022) 2011 Results article in https://pubmed.ncbi.nlm.nih.gov/21966393/ (added 23/05/2022) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33564824/ post hoc analysis (added 23/05/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2004-12-01
• Study Start: 2005-05-16
• Last Update Posted: 6 June 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 819

Inclusion Criteria

1. 50 - 70 years old
2. Men and post-menopuasal women
3. Vitamin B12 greater than or equal to 200 pmol/l
4. Homocysteine greater than or equal to 13 umol/l

Exclusion Criteria

1. Current use of vitamin supplements containing B vitamins
2. Hormone replacement therapy or lipid-lowering therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified