Folic acid and carotid intima-media thickness: a 3-year RCT examining the effects of folic acid supplementation on vascular disease.
Completed
- Registration Number
- NL-OMON21998
- Brief Summary
1. Atherosclerosis. 2005 Apr;179(2):285-92. Epub 2004 Dec 15; <br> <br><br> 2. Neurobiol Aging. 2006 Feb;27(2):334-43. Epub 2005 Feb 24;<br> <br><br> 3. Lancet. 2007 Jan 20;369(9557):208-16;<br> <br><br> 4. J Nutr Health Aging. 2007 Jul-Aug;11(4):320-4; <br> <br><br> 5. Lancet. 2007 Jul 21;370(9583):216; <br> <br><br> 6. Am J Clin Nutr. 2007 Nov;86(5):1479-85.<br>
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 819
Inclusion Criteria
1. 50-70 years old;
2. Men and post-menopuasal women;
Exclusion Criteria
1. No current use of vitamin supplements containing B vitamins;
2. No hormone replacement therapy or lipid-lowering therapy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Progression in intima-media thickening of the common carotid artery, progression in carotid arterial stiffening, decline in cognitive performance using a battery of test, decline in hearing threshold levels.
- Secondary Outcome Measures
Name Time Method