Vitamin-D level in severe infection and its outcome in patients admitted to the medical intensive care unit

Not Applicable

• Conditions: Health Condition 1: O- Medical and Surgical

• Registration Number: CTRI/2024/03/064845
• Lead Sponsor: Research and development department, Datta Meghe institute of higher education and research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 1 April 2024

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

After written inform consent all the patients of more than 18 years of age who will be screened clinically for sepsis and low vitamin D levels, relevant biochemical analysis will be done and they will be considered for study if they met the accepted definition for sepsis:

 1) confirmed or suspected source of infection determined by the treating clinician and/or a serum lactate level .2.5 mmol/L1.

 

 2) Two or more criteria for the systemic inflammatory response syndrome (SIRS), defined as:

a) Temperature greater than 38C or less than 36C1.

b) Respiratory rate greater than 20 breaths per minute or partial pressure of carbon dioxide less than 32 mm Hg1.

c) Heart rate greater than 90 beats per minute1.

d) White blood cell count greater than 12,000 or less than 4,000 cells per mm3, or greater    than 10% immature forms1

 

3) Presence of hypotension (mean arterial pressure,70 mm Hg or systolic blood pressure,90 mm Hg) despite adequate fluid resuscitation or requiring vasopressor therapy1.

 

In the inclusion criteria, patients will be further divided into  classes according to the values of Vitamin D:

      Reference level     :  30ng/ml.

      Insufficient            : 20-29ng/ml.

      Deficient                :11-20ng/ml

      Severely deficient  : less than 10ng/ml12.

Exclusion Criteria

Exclusion criteria1

1)Pregnant and lactating mothers.

2)Post cardiopulmonary resuscitated patient.

3)Patient taking multivitamin, or food supplements which contain Vitamin D.

4)Patient with malabsorption syndromes.

5)Patients with chronic diarrhea.

6)Patients not willing to give informed consent

Study & Design

• Study Type: Observational
• Study Design: Not specified