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Clinical Trials/ISRCTN82391603
ISRCTN82391603
Completed
N/A

Cardiovascular effects of empagliflozin in diabetes mellitus

niversity of Leeds0 sites36 target enrollmentOctober 16, 2018

Overview

Phase
N/A
Intervention
Not specified
Conditions
Circulatory System
Sponsor
niversity of Leeds
Enrollment
36
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/34182806/ (added 13/08/2021)

Registry
who.int
Start Date
October 16, 2018
End Date
June 30, 2022
Last Updated
3 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
niversity of Leeds

Eligibility Criteria

Inclusion Criteria

  • 1\. Type 2 diabetes mellitus
  • 2\. Metformin as single or dual therapy
  • 3\. Recent heart attack (\<12 months)
  • 4\. HbA1c \>48mmol/ml
  • 5\. 18\-84 years old
  • 6\. Ability to provide informed consent

Exclusion Criteria

  • 1\. Previous coronary artery bypass grafting (CABG)
  • 2\. Need for further revascularisation
  • 3\. Contra\-indication to CMR scanning (some pacemakers, intraorbital debris, intraauricular implants, intracranial clips etc)
  • 4\. Contra\-indication to Adenosine
  • 5\. Known allergy to contrast medium (gadolinium)
  • 6\. Renal dysfunction with eGFR\< 60
  • 7\. Obesity where girth exceeds the scanner bore
  • 8\. Pregnancy or breastfeeding
  • 9\. Inability to lie flat for CMR scan

Outcomes

Primary Outcomes

Not specified

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