The Effects of Artificial Lighting on Affective and Core Symptoms of Eating Disorder - a Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anorexia Nervosa
- Sponsor
- Mental Health Services in the Capital Region, Denmark
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- 3 week change in total score of Major Depression Inventory
- Status
- Terminated
- Last Updated
- 2 years ago
Overview
Brief Summary
The primary objective of this pilot study is to explore the effect of artificial lighting on affective symptoms, and the secondary aim is to explore the effect of artificial lighting on core symptoms of eating disorders (ED).
Several lines of evidence, albeit from hypothesis generation studies, suggest that artificial lighting may have a positive effect on well-being, mental health and affective symptoms in ED. The rationale of this study is to investigate the effects of artificial lighting on affective symptoms and cores symptoms of ED in inpatients undergoing weight restoration/treatment for ED.
Study design: Single-blind, controlled, pilot intervention study with circadian light (CL) comparing two CL regimens effects on mood symptoms.
Planned number of subjects: 16 patients with a ICD-10 diagnosis of Anorexia Nervosa, that completes exposure to at least three weeks of the two different CL regimens (L1 and L2) in any order.
Detailed Description
The primary objective of this pilot study is to explore the effect of artificial lighting on affective symptoms, and the secondary aim is to explore the effect of artificial lighting on core symptoms of eating disorders (ED). If an effect is indicated, the study will provide information on how to improve light exposure to ED patients in psychiatric treatment units. In addition, the outcomes may help identify a better system for measurement and adjustment of the specific light variables of colour temperature and light intensity. Several lines of evidence, albeit from hypothesis generation studies, suggest that artificial lighting may have a positive effect on well-being, mental health and affective symptoms in ED. This is the rationale to investigate the effects of artificial lighting on affective symptoms and cores symptoms of ED in inpatients undergoing weight restoration/treatment for ED. Study design: Single-blind, controlled, pilot intervention study with circadian light (CL) comparing two CL regimens effects on mood symptoms. Planned number of subjects: 16 patients with a International Classification of Disorders 10 (ICD-10) diagnosis of Anorexia Nervosa, that completes exposure to at least three weeks of the two different CL regimens (L1 and L2) in any order. Location: Mental Health Center Ballerup, department 14 (currently Department 5). Diagnostic inventory: Eating Disorder Examination-Questionnaire (EDE-Q)
Investigators
Eligibility Criteria
Inclusion Criteria
- •Primary diagnosis of Anorexia Nervosa (AN) or Bulimia Nervosa (BN) or Eating Disorder Not Otherwise specified (EDNOS)
- •Age ≥18 and \<65
Exclusion Criteria
- •Forced care
- •Non-primary psychiatric disorder other than AN, BN, or EDNOS
- •Binge Eating disorder
- •Somatic unstable condition
- •High suicidal behavior or risk
Outcomes
Primary Outcomes
3 week change in total score of Major Depression Inventory
Time Frame: 3 weeks change from baseline
depression scoring, change in total score over three weeks. range 0-50. Higher values means more depressed. Mild depression: MDI total score from 21 to 25. Moderate depression: MDI total score from 26 to 30. Severe depression: MDI total score of 31 or higher.
3 week change in video images based measure of Physical activity
Time Frame: 3 weeks change in physical activity from baseline
video images based measure of quantity of physical activity
3 week change in total score of Eating Disorder Inventory 2
Time Frame: 3 weeks change from baseline
Eating disorder symptoms total score change over 3 weeks. range 0-273. Higher score means more Eating disorder symptoms.
Secondary Outcomes
- 3 week change in melatonin levels(3 weeks change from baseline)
- 3 week change in cortisol levels(3 weeks change from baseline)
- 3 week change in BMI(3 week change as a measure of weight change)
- 3 week change in Visual analogue scale of mood(3 weeks change from baseline)
- 3 week change in serotonin levels(3 weeks change from baseline)