Osteoarthrosis on 7.0T Magnetic Resonance Imaging
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- MRI
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- The thickness of the cartilage of patellar on 7T MRI scan
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting osteoarthrosis. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater agreement. Diagnostic procedures such as 7T MRI may help ultimately improved diagnostic and therapies confidence to inform decision making than standard 3T MRI.
Detailed Description
7T MRI increased detection sensitivity, attain superior anatomic resolution, higher spatial and spectral specificity of advanced quantitative techniques, and shorter scan times than 3T MRI. When applied clinically, these benefits translate to increased detection sensitivity, and ultimately improved diagnostic and therapies confidence to inform decision making. This study aim to detect the image characteristics and diagnostic accuracy of osteoarthrosis on 7T MRI.
Investigators
Xin Lou
Director and Clinical Professor
Chinese PLA General Hospital
Eligibility Criteria
Inclusion Criteria
- •Age≥18 and ≤80
- •Having no contraindications against MRI
- •Clinically stable
Exclusion Criteria
- •Age#18 or #80
- •Pregnancy and other contraindication to MRI scan
- •Informed consent not obtained
Outcomes
Primary Outcomes
The thickness of the cartilage of patellar on 7T MRI scan
Time Frame: baseline
Thickness of different part of the cartilage of patellar measured based on axial PD images
The T2 mapping value of the patellar cartilage on 7T MRI scan
Time Frame: baseline
T2 relaxation times of the patellar cartilage measured based on T2 mapping
The abnormal signal in the infrapatellar fat pad
Time Frame: baseline
The exist of abnormal signal in the infrapatellar fat pad detected based on sagittal PD images
Secondary Outcomes
- Signal change of the patellar chondral before and after rehabilitation(1 month after rehabilitation)
- Signal change of the infrapatellar fat pad before and after rehabilitation(1 month after rehabilitation)