Improving Non-Invasive Diagnosis and Grading of Cartilage Defects in the Knee - Accuracy of Ultra High Field 7-Tesla MRI as Compared With Arthroscopy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cartilage Injury
- Sponsor
- The Methodist Hospital Research Institute
- Enrollment
- 112
- Locations
- 1
- Primary Endpoint
- Modified Whole-Organ Magnetic Resonance Imaging Score (WORMS)
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The investigators propose to prospectively evaluate the accuracy of a novel 7-Tesla (7T) knee MRI protocol for the detection and grading of cartilage lesions in the knee, which is a significant limitation of current MRI techniques.
Detailed Description
The investigators hypothesize that 7T MRI will be \~ 80% sensitive for detection of cartilaginous lesions. This will be tested in a prospective multi-reader study of 100 patients who are scheduled to have knee arthroscopy. Patients will have two MRIs of the knee: one standard of care and one experimental 7T MRI. Subjects will visit at one time point prior to scheduled knee arthroscopy, for a session time of \~1-2 hours for a single 7T MRI scan.
Investigators
Patrick McCulloch,MD
Principal Investigator
The Methodist Hospital Research Institute
Eligibility Criteria
Inclusion Criteria
- •Confirmed Knee Symptomatology
- •Scheduled Arthroscopic Treatment of Knee
- •Adult (equal or greater than 18 years of age)
Exclusion Criteria
- •Active infections
- •Less than 18 years of age
Outcomes
Primary Outcomes
Modified Whole-Organ Magnetic Resonance Imaging Score (WORMS)
Time Frame: baseline
* Modified Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee is a validated instrument utilized to grade structural abnormalities found in MRI. * Only the cartilage sub-score of the full WORMS will be scored in the study. Cartilage will be scored on a range from 0-6 for 6 different regional subdivisions for a minimum score of 0 and maximum score of 36. A lower score is considered a better outcome, with a score of 0 equating to normal thickness and signal of cartilage.