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临床试验/NCT04463862
NCT04463862已完成不适用

Air Pollution and COVID-19 Mortality in Geriatric Patients: a Multicenter Study

University Hospital, Strasbourg, France8 个研究点 分布在 2 个国家目标入组 660 人开始时间: 2020年6月4日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
660
试验地点
8
主要终点
COVID-19 related-mortality

研究概览

简要总结

Epidemiological data have related particulate matter (PM), nitrogen dioxide (NO2) and ozone (O3) to COVID-19 morbidity and mortality at the population level. Air pollution may be related to an increase in the COVID-19 severity and lethality through its impact on chronic diseases such as cardiovascular and respiratory diseases and diabetes that are also the main comorbidities associated with COVID-19. Epidemiological studies using individual data are needed to provide more precise estimate of the association between air pollution exposure and COVID-19. In this multicenter prospective study, the investigators will analyze the number of deaths in COVID-19 confirmed cases in geriatric patients according to long-term exposure to air pollution, taking into account confounders such as diabetes, hypertension, age, and BMI. Exposure to air pollution will be estimated as the mean concentration of air pollutants at the residential address during the previous two years. In addition, the investigators will explore the relationship between short-term variations in air pollutants, relative humidity, temperature, UV radiations, pollen and the occurrence of COVID-19.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Other

入排标准

年龄范围
50 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patient over 60 years old (or dementia patient over 50 years old)
  • Patient hospitalized in a geriatric department over the period from 2020/01/01 to 2020/06/01
  • Patient who underwent RT-PCR SARS-CoV-2
  • Patient (or trusted person/ legal guardian/curator, if applicable) who has given consent to the re-use of his/her data (patient data) for research purposes

排除标准

  • 未提供

结局指标

主要结局

COVID-19 related-mortality

时间窗: COVID-19 mortality between 2020/01/01 and 2020/06/01

Association between COVID-19 related-mortality and air pollutants concentrations estimated at the residential address of geriatric patients during the last 2 years ( from 2018/01/01 to 2019/12/31)

次要结局

  • COVID-19 confirmed cases(COVID-19 confirmed cases between 2020/01/01 and 2020/06/01)

研究者

发起方
University Hospital, Strasbourg, France
申办方类型
Other
责任方
Sponsor

研究点 (8)

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