How do thick airway walls affect airway hyperresponsiveness in asthma.

Phase 4

Completed

• Conditions: Asthma; Respiratory - Asthma

• Registration Number: ACTRN12610000561088
• Lead Sponsor: The Woolcock Institute of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-07-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

doctor-diagnosed asthma; current symptoms of asthma; airway hyperresponsiveness to methacholine; taking no more than 800ug Beclomethasone diproprionate (BDP) equivalent/day;

Exclusion Criteria

current smokers within the last year or having more than 10 years pack history; pregnancy; history of lung cancer, lung reduction surgery, major illness (heart attack, stroke, epilepsy, rheumatoid arthritis); respiratory infection or oral pregnisolone use within the four weeks prior to study participation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in airway wall thickness, measured using high resoution computed tomography (HRCT) scans, during 3 months treatment correlates with a change in airway responsiveness, measured using methacholine bronchial challenge tests.[after 3 months of treatment];correlation between airway stiffness, measured using the forced oscillation technique, and airway responsiveness, measured using methacholine bronchial challenge tests[before and after 3 months of treatment]

Secondary Outcome Measures

Name	Time	Method
correlation between airway wall thickening, measured using high resoution computed tomography (HRCT) scans, and airway stiffness, measured using the forced oscillation technique.[before and after 3 months of treatment]