Small Airway function in obesity and asthma study

Completed

Conditions: asthma
10024967

Registration Number: NL-OMON45982

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

* Age * 18 who have signed informed consent form prior to the start of the study
* Clinical diagnosis for * 6 months of asthma
* Stable asthma: on a stable dose of asthma inhalation medication for at least 8 weeks prior to baseline visit
* Obese (BMI >30) or non-obese (BMI <30)

Exclusion Criteria

* Change of asthma inhalation medication in the past 8 weeks before visit 1
* Asthma exacerbation (defined as use of oral or intravenous corticosteroids and/or antibiotics) in the past 8 weeks before visit 1
* Smokers: current * 10 cigarettes per day or *10 pack years
* Diagnosis of COPD
* Pregnancy, as reported by the participant
* Clinical or functional uncontrolled respiratory- or other disease that might, in the judgement of the investigator, comprise the results or interpretation of the study
* Current- or less than 1 month from baseline participation in interventional clinical trial with inhalation drugs
* Inability to comply with study procedures

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Compare available tests for small airway function in asthmatic patients. The<br /><br>primary endpoint is Impulse Oscillometry.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other small airway measurements:<br /><br>- spirometry<br /><br>- multiple breath nitrogen washout<br /><br>- body plethysmography<br /><br>- RGA Single breath CO-diffusion (TLCO, KCO, VA)<br /><br>- fraction exhaled nitric oxide<br /><br><br /><br>Other airway tests<br /><br>- methacholine provocationtest<br /><br>- eosinophils in sputum en blood<br /><br><br /><br>Questionnaires:<br /><br>- Asthma control<br /><br>- Bronchial hyperreactivity<br /><br>- Asthma specific quality of life<br /><br>- Small Airway Disease<br /><br>- Medication adherence</p><br>