BRCA mutations and Ovarian ageing in women applying for in vitro fertilization and preimplantation genetiC diAgnosis
Completed
- Conditions
- BRCA1/2, ovarian reserve (AFC, AMH, ovarian response), ongoing pregnancy BRCA1/2, ovariele reserve (AFC, AMH, ovariele response), doorgaande zwangerschap
- Registration Number
- NL-OMON21616
- Lead Sponsor
- Participating sites: UMC Utrecht, Maastricht UMC+, Academic Hospital Brussels, UMC Groningen, Academic Medical Center Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 125
Inclusion Criteria
Case group (BRCA mutation carriers)
- Female age > 18 years and < 40 years
Exclusion Criteria
Case group (BRCA mutation carriers)
- Ovarian surgery
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum AMH level
- Secondary Outcome Measures
Name Time Method - AFC<br /><br>- Amount of poor response (less than 4 oocytes at retrieval or cancellation due to insufficient follicle growths, i.e. < 4 dominant follicles sized ¡Ý14 mm growing)<br /><br>- Number of retrieved oocytes (total amount and MII) after first cycle COH<br /><br>- Ongoing and clinical pregnancy rate <br>