BRCA mutations and ovarian ageing in normo-ovulatory wome

Completed

• Conditions: 10074469; ageing of the ovaries; ovarian ageing

• Registration Number: NL-OMON37959
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 240

Inclusion Criteria

Female with an age ranging between 18-45 years
Women with predictive genetic testing on BRCA mutation due to family history, or women with a known BRCA mutation carrier status
regular menstrual cylce
written informed consent

Exclusion Criteria

surgical menopause
ovarian surgery
chemo-or radiation therapy
Known human immunodeficiency virus (HIV) infection
Known endocrine or autoimmune abnormalities
genetic abnormalities, others than a BRCA mutation, associated with primary ovarian insufficiency

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Ovarian ageing, measured by age specific serum AMH level.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Reproductive health/outcome, which is measured by:<br /><br>- subfertility<br /><br>- fertility treatment<br /><br>- parity<br /><br>- miscarriage/abortion<br /><br>- life birth (and gender outcome)<br /><br>- pregnancy success rate (number of pregnancies/ amount of life birth)</p><br>