The effect of nutrition in cardiac surgical patients on heart function.
Completed
- Conditions
- Coronary artery disease, heart failure.Coronair lijden, hartfalen.
- Registration Number
- NL-OMON20597
- Lead Sponsor
- Academic Medical Center University of Amsterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
1. Patients who have to undergo an off-pump coronary artery bypass grafting (CABG) operation;
2. Aged 18 till 81 years.
Exclusion Criteria
1. Combined valve and CABG procedures;
2. Aged <18 and > 80 years;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study outcomes are concentrations of amino acids, and methylated arginines in blood plasma and cardiac tissue, and cardiomyocytes functioning assessed by histology.
- Secondary Outcome Measures
Name Time Method The secondary study outcomes are cardiac perfusion, and cardiac fatty acid and glucose metabolism, measured by myocardial scintigraphy and positron emission tomography.
Related Research Topics
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How does perioperative parenteral nutrition modulate amino acid profiles and cardiomyocyte function in cardiac surgery patients?
What is the comparative effectiveness of parenteral vs. enteral nutrition on cardiac perfusion and metabolism in coronary artery disease patients?
Which amino acid biomarkers predict improved cardiac outcomes in heart failure patients receiving perioperative nutritional support?
What are the potential adverse events of parenteral nutrition in cardiac surgery and their management strategies?
Are there combination therapies with specific nutrients enhancing cardiac recovery post-surgery in ischemic heart failure patients?