Effect of Intravenous Adenosine on neuro-psychological dysfunction post coronary artery bypass surgery
Phase 1
- Conditions
- euro psychological dysfunction post cardiac by-pass surgery
- Registration Number
- EUCTR2005-002794-79-GB
- Lead Sponsor
- Swansea NHS Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Aged 18 or older having first time isolated CABG
Written informed consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Steroid usage, pregnancy, Atrial venticular black or sinus node dysfunction - Bronchoconstrictive disease/hypersensitivity to adenosine
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To assess if adenosine has a neuro protective effect in patients undergoing cardiac by-pass surgery;Secondary Objective: Assess the changes in haemodynamic status ie inotropic requirements etc;<br> Primary end point(s): Primary endpoint<br> To assess whether adenosine has a neuro-protective effect which is clinically translated into improvement of neuro-psychometric dysfunction when tested by the CANTAB” neuro-psychometric tests.<br><br> Secondary endpoint<br> Will assess the changes in the haemodynamic status, inotropic requirement, mediastinal haemorrhage and blood product requirement of patients treated with adenosine.<br>
- Secondary Outcome Measures
Name Time Method