Effect of different doses of adenosine Zusanli injection on pain after laparoscopic cholecystectomy
Phase 1
- Conditions
- laparoscopic cholecystectomy
- Registration Number
- ChiCTR2400089016
- Lead Sponsor
- Shanghai Fourth People's Hospital affiliated to Tongji University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Age = 18 years;<br>2) Patients proposed for laparoscopic cholecystectomy;<br>3) BMI of 18-30 kg/m2;<br>4) ASA classification I to III;<br>5) Signing of informed consent Voluntarily.
Exclusion Criteria
- Second or third degree atrioventricular block, sick sinus node syndrome (except patients with artificial pacemakers) ;<br>2)Patients with pulmonary disease with bronchial stenosis or bronchospasm (such as asthma);<br>3)Patients with hypersensitivity to adenosine;<br>4)Persons with communication disorders that prevent them from cooperating with the researcher, such as language comprehension disorders, psychiatric disorders;<br>5)Those who have had a heart attack or cerebral infarction within six months;<br>6)Pregnant or lactating women;<br>7)Infection at the acupuncture point injection site;<br>8)History of analgesic medication for a continuous period of 3 months prior to enrollment;<br>9) Other conditions that considered inappropriate for inclusion by the investigators.<br><br>
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain VAS score;
- Secondary Outcome Measures
Name Time Method Time of first exhaust ;Time of first bowel ;Time of first water intake;Incidence of nausea and vomiting;Blood interleukin-18 concentration at 6h postoperatively;Intraoperative sufentanil and remifentanil dosage;Intraoperative heart rate and mean arterial pressure;Postoperative Pittsburgh Sleep Quality Score ;Complications associated with acupoint injections;Remedial analgesic dosage;Patient Satisfaction Score;